Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis.
نویسندگان
چکیده
منابع مشابه
Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis
We have compared the sensitivity of clonogenic interleukin 7 (IL-7)-dependent murine B cell precursors with that of clonogenic mature B cells and myeloid precursors to alpha-particles from plutonium-238 and X radiation. All three populations are relatively sensitive, but B cell precursors are ultrasensitive. This differential sensitivity is also observed with corticosteroid, etoposide, and cisp...
متن کاملInterleukln 7-dependent B Lymphocyte Precursor Cells Are Ultrasensitive to Apoptmis
From the *Leuhaemia Research Fund Centre, Institute of Cancer Research, London SW3 6JB; the eMRC Radiobiology Unit, Didcot 0XI10Rs United Kingdom; the $Oncogene and Tumor Suppressor Gene Program, La Jolla Cancer Research Foundation, La Jolla, California 92037; and the IIDepartment of Medicine, Microbiology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine...
متن کاملInterleukln 7 - dependent B Lymphocyte Precursor Cells Are
From the *Leuhaemia Research Fund Centre, Institute of Cancer Research, London SW3 6JB; the eMRC Radiobiology Unit, Didcot 0XI10Rs United Kingdom; the $Oncogene and Tumor Suppressor Gene Program, La Jolla Cancer Research Foundation, La Jolla, California 92037; and the IIDepartment of Medicine, Microbiology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine...
متن کاملDifferentiation of an interleukin 3-dependent precursor B-cell clone into immunoglobulin-producing cells in vitro.
Precursors to B-cell lines with immunoglobulin genes in the germ-line context have been shown to be capable of generating mature B cells in vivo. We report here that an interleukin 3-dependent precursor B-cell line, LyD9, differentiated in vitro into mature B cells, producing IgM and IgG by coculture with bone marrow accessory (or stroma) cells or with dendritic cells and T cells. Up to 50% of ...
متن کاملApoptosis and interleukin 7 gene expression in chronic B-lymphocytic leukemia cells.
mRNA for interleukin 7 (IL-7) was readily detected in leukemic cells immediately upon their removal from patients with chronic B-lymphocytic leukemia (B-CLL). IL-7 mRNA expression and IL-7 gene transcription were down regulated, however, when B-CLL cells were placed in culture at 37 degrees C for 4 hr. Down regulation of the IL-7 gene was prevented in cells maintained at 4 degrees C. Continued ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1994
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.179.6.1789